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Updated: Jul 25, 2025

Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay
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Conformational Evaluation of HIV-1 Trimeric Envelope Glycoproteins Using a Cell-based ELISA Assay

Published on: September 14, 2014

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两个创始病毒的抗原压力会在单个抗体位置诱导多个插入,从而产生广泛中和的HIV抗体

Collin Joyce1,2,3, Sasha Murrell4, Ben Murrell5,6

  • 1Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.

PLoS pathogens
|June 29, 2023
PubMed
概括

开发强大的广泛中和抗体 (bnAbs) 由于独特的抗体特征而具有挑战性. 这项研究揭示了多种艾滋病毒创始病毒的暴露如何引起bnAbs,为未来的疫苗设计提供信息.

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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
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Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
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