在生命之树上,仿真主义是否与癌症有关?
Stefania E Kapsetaki1,2, Angelo Fortunato1,2, Zachary Compton1,2,3
1Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ, United States of America.
PloS one
|June 29, 2023
概括
较高水平的嵌合体,一个生物体内具有遗传特异性的细胞的存在,与多细胞生命中瘤侵入性增加相关. 这表明,金马主义和癌症进展之间存在联系.
科学领域:
- 进化生物学 进化生物学
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 化学性,即在单个生物体内存在遗传上不同的细胞群,在各种物种中都能观察到.
- 嵌合体中耐受非自身细胞的能力可能会影响疾病易感性,包括癌症.
研究的目的:
- 为了研究嵌合体和癌症患病率和特征之间的关联,在有义务的多细胞生物.
- 为了确定嵌合体水平是否与瘤侵入性,新生病和生命树上的恶性瘤相关.
主要方法:
- 根据现有的文献,将12种强制性多细胞类型分类为嵌合体级别.
- 对11种陆地哺乳动物种类的瘤侵入性,新生病和恶性瘤的分析.
主要成果:
- 在研究的种群中,在更高的嵌合体水平和增加的瘤侵入性之间发现了积极的关联.
- 在哺乳动物中,没有观察到嵌合体和瘤或恶性瘤患病率之间的显著关联.
结论:
- 化学作用可能在易受侵袭性癌症的作用中发挥作用,突出显示了潜在的生物联系.
- 对嵌合体的进一步研究可能会揭示侵入性癌症的机制,并为传染性癌症的检测和管理提供信息.
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