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Updated: Jul 25, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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在分子分辨率上空间分辨的单细胞转基因

Hu Zeng1,2, Jiahao Huang1,2, Jingyi Ren1,2

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Science (New York, N.Y.)
|June 29, 2023
PubMed
概括

研究人员开发了RIBOmap,这是一种在单细胞中绘制信使RNA (mRNA) 翻译的新方法. 这项技术揭示了细胞特异性的基因表达模式和大脑中的局部翻译.

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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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