与VACTERL相关的个体的神经发育结果. 一个基于人口的队列研究
Ann-Marie Kassa1,2, Helene Engstrand Lilja3,4
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
PloS one
|June 29, 2023
概括
患有VACTERL关联的人患注意力缺陷多动症障碍 (ADHD),自闭症谱系障碍 (ASD) 和智力障碍 (ID) 的风险明显更高. 早期诊断和支持对于改善他们的生活质量至关重要.
科学领域:
- 医学研究 医学研究
- 发育儿科 发育儿科
- 遗传学和罕见疾病.
背景情况:
- VACTERL关联是一种复杂的先天性疾病,涉及多种形,通常需要新生儿手术.
- 神经发育障碍,包括ADHD,ASD和ID,是大脑发育的干扰,在VACTERL患者中对其流行率的研究有限.
- 现有的关于手术治疗新生儿神经发育结果的研究很少,并产生相互矛盾的结果.
研究的目的:
- 研究被诊断患有VACTERL关联的人群中注意力缺陷多动症 (ADHD),自闭症谱系障碍 (ASD) 和智力障碍 (ID) 的风险.
- 为参与VACTERL患者长期护理的护理人员和医疗保健专业人员提供关键数据.
主要方法:
- 利用来自瑞典四个国家卫生登记处的数据进行一项队列研究.
- 包括136个1973-2018年间出生的与VACTERL协会的个人.
- 采用了考克斯的比例危险模型,对680个匹配的健康对照进行了匹配.
主要成果:
- 与对照组相比,与VACTERL相关的个体具有显著增加的ADHD (2.25倍),ASD (5.15倍) 和ID (8.13倍) 的风险.
- 该研究在VACTERL队列中确定了关键神经发育障碍的特定风险增加.
结论:
- VACTERL的相关性与ADHD,ASD和ID的风险大大增加有关.
- 这些发现强调了早期检测和针对VACTERL患者的有针对性的支持的重要性,以提高他们的发育结果和整体生活质量.
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