抗血素缺乏症:患有血栓症和血栓性家族患者的频率
Maria Anna Pejková1, Eva Ivanová1, Petr Sadílek1
14th Department of Internal Medicine - Hematology, Faculty Hospital, Charles University, Faculty of Medicine in Hradec Králové, Hradec Králové; Czech Republic.
Acta medica (Hradec Kralove)
|June 29, 2023
概括
抗血素缺乏是静脉血栓栓塞 (VTE) 的重要危险因素,特别是在年轻患者中. 建议对45岁以下无其他风险因素的血栓形成患者进行检测,包括孕妇和使用口服避孕药的人.
科学领域:
- 血液学 血液学 血液学
- 遗传学 遗传学 是一个
- 血管医学 血管医学
背景情况:
- 抗血素 (AT) 缺乏是静脉血栓塞栓症 (VTE) 的遗传风险因素.
- 最近的重点转移到因子V Leiden和因子II 20210a突变,可能会掩盖AT缺乏症.
- 了解不同患者群体中AT缺乏症的患病率对于适当的诊断策略至关重要.
研究的目的:
- 为了确定不同患者队列中抗血素缺乏的频率.
- 为了建立抗血素缺乏检测的明确指示.
- 重新评估在血栓友爱症工作中抗血栓素检测的临床效用.
主要方法:
- 在不同患者队伍中分析抗血素缺乏的频率.
- 结果的分层基于VTE复发,血栓的位置和相关的风险因素 (例如,口服避孕药,怀孕).
- 临床评估以确定患有血栓形成的患者并评估风险因素.
主要成果:
- 在4%的50岁以下复发性VTE患者中发现了抗素缺乏症.
- 在患有脊柱静脉血栓症的患者中观察到1%的患病率.
- 2%的与联合口服避孕药使用或怀孕相关的病例显示出抗血缺乏症.
- 在中枢静脉血栓症患者中没有检测到抗血缺乏症.
结论:
- 对45岁以下的患有血栓形成而没有可识别的风险因素的患者,抗血栓素检测是有价值的.
- 检测特别适用于怀孕期间,产后期或口服避孕药使用的第一年内出现VTE的妇女.
- 尽管对综合性血栓性查的兴趣在下降,但在特定情况下,抗血栓检测仍然具有临床相关性.
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