大脑/脑海连接资源:一个开放式访问平台用于灵长类大脑中细胞水平的追踪和曲谱
Henrik Skibbe1, Muhammad Febrian Rachmadi1, Ken Nakae2
1Brain Image Analysis Unit, RIKEN Center for Brain Science, Wako, Saitama, Japan.
PLoS biology
|June 29, 2023
概括
大脑/头脑大猩猩连接资源 (BMCR) 为大猩猩前额叶皮层提供高分辨率的大脑映射数据. 这种开放式访问平台集成了多种数据类型,用于先进的连接分析.
科学领域:
- 神经科学是一个神经科学.
- 灵长类动物大脑解剖学
- 在Connectomics上,我们提供了连接.
背景情况:
- 灵长类动物的大脑具有独特的结构,可实现高级认知功能.
- 了解大脑结构对于开发准确的功能模型至关重要.
研究的目的:
- 介绍大脑/思维的马尔莫塞特连接资源 (BMCR).
- 提供开放访问,高分辨率的神经元追踪器数据,用于大黄蜂大脑.
- 实现跨个体和模式的连接数据的综合分析.
主要方法:
- 实施BMCR平台的前进和逆向神经元追踪器数据.
- 扩散MRI通道图数据的整合.
- 在一个共同的参考空间内开发数据探索和审查工具.
主要成果:
- BMCR提供了前所未有的分辨率来分析连接特征,如互惠性和定向性.
- 当前发布的重点是马尔莫塞特前额叶皮层 (PFC),包括52个前向和164个逆向的标记器注射.
- 包括通道图数据允许对细胞连接进行验证,有助于未来的通道图开发.
结论:
- 该BMCR促进了灵长类大脑连接的详细分析,特别是在PFC.
- 该平台的综合方法和高分辨率推进了对大脑结构功能关系的研究.
- BMCR 作为神经科学研究和大脑模型开发的宝贵资源.
相关概念视频
00:49The Blood-brain Barrier
Overview
01:21Cerebrospinal Fluid
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
01:23Brain Waves
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics: