皮质纤维瘤原生体的生存结果和预后因素:基于人口的回顾性队列分析
Shijing Chen1, Lidan Xiong2, Lingyun Zhao1
1Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.
概括
皮质纤维素瘤突起体 (DFSP) 总体而言具有良好的预后. 然而,高度或大DFSP瘤 (≥10厘米) 与癌症特异性死亡率的增加有关.
科学领域:
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
- 手术病理学手术病理学
背景情况:
- 关于皮肤纤维瘤突起体 (DFSP) 的生存结果和危险因素的数据有限.
- 了解预后因素对于管理这种罕见的软组织肉瘤至关重要.
研究的目的:
- 为了研究DFSP的临床病理学特征.
- 确定DFSP患者的生存结果并确定预后因素.
主要方法:
- 来自监测,流行病学和最终结果 (SEER) 计划 (2000-2018) 的大量队列 (7567名患者) 的分析.
- 评估人口统计学,临床病理学变量,生存数据和预后因素.
- 统计分析以确定癌症特异性死亡率的独立风险因素.
主要成果:
- DFSP瘤主要位于皮肤 (74.53%) 和软组织 (25.47%) 中.
- 那些死于DFSP的患者的中位生存时间为41个月.
- 死亡的独立风险因素包括晚年,较高的组织学级 (III级) 和较大的瘤大小 (≥10厘米).
- 瘤位置和外科手术没有显著影响生存结果.
结论:
- DFSP表现出有利的生存预后,即使有淋巴结或远程转移.
- 组织学级III和大瘤大小 (≥10厘米) 是增加DFSP特异性死亡率的显著预测因素.
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