通过向炎症和亡信号通路,Acacia senegal对毒症的脏保护作用
Obeid Shanab1, Samir M El-Rayes2, Waleed F Khalil3
1Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt.
Ecotoxicology and environmental safety
|June 29, 2023
概括
阿卡西亚口香糖通过减少炎症和氧化应激减轻损伤,防止阿弗拉托克辛B1 (AFB1) 的损伤. 这项研究表明,牙补充剂可能有助于预防AFB1诱导的毒性.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 自然产品化学 自然产品化学
背景情况:
- 非洲毒素B1 (AFB1) 是一种普遍存在的环境毒素,造成人类和动物健康的重大风险.
- 阿卡西亚 (Gum) 具有已知的抗氧化和抗炎性质.
- 暴露于AFB1会导致严重的损伤,其特征是功能和组织学变化.
研究的目的:
- 为了研究白银对AFB1诱导的损伤的脏保护潜力.
- 阐明AFB1诱导的毒性和口香糖的保护作用的潜在机制.
主要方法:
- 鼠被分为四组:对照组,牙组,AFB1组和AFB1-牙组联合治疗.
- 分析了功能参数,组织结构和炎症和亡标志物的基因/蛋白质表达.
- 的植物化学成分使用气色谱-质谱法 (GC/MS) 进行了鉴定.
主要成果:
- 暴露于AFB1显著损害了功能和改变了组织学.
- AFB1增加了炎症标志物 (IL-6,TNFα, iNOS,NF-κB/P65) 和亡标志物 (Cyto c,Caspase3).
- 补充口香糖可以抵消AFB1诱导的损伤,减少炎症,氧化应激 (Nrf2,SOD1) 和亡.
结论:
- 阿卡西亚对AFB1诱导的损伤具有显著的保护作用.
- 这些保护作用归因于口香糖的抗氧化和抗炎活性.
- 建议作为食添加剂补充口香糖,以减轻AFB1诱导的毒性.
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