肠道微生物群和饮食成分摄入与COVID-19的关联:孟德尔的随机化研究
1Department of General Practice, Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu, China.
Clinical nutrition (Edinburgh, Scotland)
|June 29, 2023
概括
这项研究表明,肠道细菌和饮食影响COVID-19风险. COVID-19还影响肠道微生物群,表明这些因素与疾病之间存在双向因果关系.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 肠道微生物组成和饮食摄入量的变化与COVID-19有关.
- 这些因素与COVID-19之间的因果关系尚不清楚.
研究的目的:
- 研究肠道微生物群和饮食成分对COVID-19的潜在因果影响.
- 探索COVID-19和肠道微生物群变化之间的双向关系.
主要方法:
- 采用了两个样本的门德尔随机化分析.
- 遗传变异作为肠道微生物群,饮食摄入量和COVID-19状态的工具变量.
主要成果:
- 几种肠道细菌属 (例如,Ruminococcustorques,Lachnospira) 显示出与COVID-19的显著关联.
- 特定的微生物种群与严重的COVID-19有关.
- 加工肉类摄入量与COVID-19有显著的关联,而牛肉摄入量则显示出一个暗示性关联.
- 盐和新鲜水果摄入等饮食因素与严重的COVID-19有联系.
结论:
- 研究结果支持肠道微生物群和饮食摄入在COVID-19中起因作用.
- 有证据表明,COVID-19对肠道微生物群组成的因果关系.
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