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Updated: Jul 25, 2025

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在单酸盐诱导的急性痛风性关节炎中,PRDM1/SIRT2/NLRP3轴的促炎作用

Qingsong Zhao1, Nan Xia1, Jinmei Xu1

  • 1Department of Endocrinology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

Journal of innate immunity
|June 29, 2023
PubMed
概括

含PR域1 (PRDM1) 通过抑制sirtuin 2 (SIRT2),增加NLRP3炎症酶激活和IL-1β释放,促进急性痛风性关节炎. 减少PRDM1的表达可以防止这种炎症状况.

关键词:
乙化α-tubulin 的使用.患有急性痛风性关节炎的人.炎症性细胞因子是可以引起炎症的.巨细胞是一个巨细胞.作为NLR家族的一员.PR域-包含1与指域.含有氨酸域的3个氨酸域.塞尔图因 2 2 在

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