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Updated: Jul 25, 2025

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通过单细胞扩张控制基因编辑的造血干细胞中的遗传异质性

Hans Jiro Becker1, Reiko Ishida2, Adam C Wilkinson3

  • 1Laboratory for Stem Cell Therapy, Faculty of Medicine, Tsukuba University, Tsukuba 305-8577, Japan; Division of Stem Cell Biology, Center for Stem Cell Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

Cell stem cell
|June 29, 2023
PubMed
概括

这项研究引入了一种扩展和基因分析个体造血干细胞 (HSC) 克隆ex vivo的方法. 这种方法确保在移植之前编辑的HSC无需不必要的突变,从而提高基因治疗的安全性和有效性.

关键词:
克里斯普尔-Cas9是什么意思化学定义的文化是一种文化.克隆扩张的扩张.活体外扩张 活体外扩张基因编辑 基因编辑基因治疗的基因疗法造血干细胞是造血干细胞的组成部分.再生医学是一种再生医学.培养干细胞培养的干细胞培养移植 移植 移植 移植

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