图形"纹理"功能作为新的指标,可以总结复杂的生物图形.
R Barker-Clarke1, D T Weaver1,2, J G Scott1,2
1Department of Translational Hematology and Oncology Research, Lerner Research Institute, Cleveland, OH 44195, United States of America.
Physics in medicine and biology
|June 29, 2023
概括
研究人员开发了新的图形纹理特征,类似于图像纹理分析,以分析生物网络. 这些特征有效地分类癌细胞系,为网络科学和癌症信息学提供了新的工具.
科学领域:
- 网络科学 网络科学
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 图像纹理特征对图像分类有价值,包括在癌症研究中.
- 分析复杂的生物网络需要先进的定量方法.
研究的目的:
- 导出图形纹理特征类似于图像纹理分析.
- 证明它们在总结,比较和分类生物网络中的实用性,特别是在癌症研究中.
主要方法:
- 通过对邻近的节点对进行总和来生成图形共发生矩阵.
- 开发并将纹理指标应用于健身景观,基因网络和蛋白质相互作用网络.
- 评估了对离散和噪声的度量敏感性;为癌细胞谱系构建了随机森林分类器.
主要成果:
- 新的图形纹理特性有效地捕捉了图形结构和节点标签分布.
- 度量表现出对参数变化和噪声的敏感性.
- 分类器在通过血统区分癌细胞系表达时实现了82%和89%的准确性.
结论:
- 新的图形纹理功能为比较分析和分类提供了新的二级网络指标.
- 这些特性显示出癌症信息学应用的前景,例如进化分析和药物反应预测.
相关概念视频
Protein Networks
4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K
Multiple Bar Graph
5.3K
As the name suggests, a multiple bar graph is the same as a bar graph but has multiple bars to depict relationships between different data values. One can include as many parameters as possible. However, each parameter must have the same unit of measurement.
Each bar or column in the multiple bar graph represents a data value. These graphs are used primarily in interrelating two or more sets of data. The categories of different kinds of data are listed along the horizontal or x-axis, whereas...
Each bar or column in the multiple bar graph represents a data value. These graphs are used primarily in interrelating two or more sets of data. The categories of different kinds of data are listed along the horizontal or x-axis, whereas...
5.3K
Time-Series Graph
4.4K
A time-series graph is a line graph with repeated measurements taken at successive intervals of time. It is also called a time series chart. To construct a time-series graph, one must look at both pieces of a paired data set. The horizontal axis is used to plot the time increments, and the vertical axis is used to plot the values of the variable that one is measuring. By using the axes in this way, each point on the graph will correspond to time and a measured quantity. The points on the graph...
4.4K
Bar Graph
16.7K
A bar graph is also called a bar chart and consists of bars that are separated from each other. It either uses horizontal or vertical bars to show comparisons among categories. The bars can be rectangles, or they can be rectangular boxes (used in three-dimensional plots). One axis of the graph represents the specific categories being compared, and the other axis shows a discrete value. In this graph, the length of the bar for each category is proportional to the number or percent of individuals...
16.7K


