用于治疗2型糖尿病患者的肥胖症 (SURMOUNT-2):双盲,随机,多中心,安慰剂对照的3期试验
在PubMed上查看摘要
概括
此摘要是机器生成的。在患有肥胖和2型糖尿病的成年人中,提尔泽帕提德在72周内显著降低了体重. 这种依赖葡萄糖的胰岛素多和类似葡萄糖-1受体激动剂在体重控制方面表现出良好的安全性.
科学领域
- 代谢和内分泌学
- 药理学
- 临床试验
背景情况
- 肥胖和2型糖尿病需要有效的减肥策略.
- 蒂尔泽帕提德是一种双GIP和GLP-1受体激动剂,用于体重控制.
研究的目的
- 对肥胖和2型糖尿病患者减肥的提泽帕提德的疗效和安全性进行评估.
- 在72周的时间内,与安慰剂进行比较.
主要方法
- 第三阶段,双盲,随机,安慰剂对照试验,涉及938名成年人.
- 参与者每周接受皮下提尔泽帕提德 (10 mg或15 mg) 或安慰剂.
- 主要终点包括体重百分比变化和体重减轻≥5%.
主要成果
- 10 mg和15 mg的提尔泽帕提德导致平均体重分别减少12. 8%和14. 7%,而安慰剂则减少了3. 2%.
- 与安慰剂 (32%) 相比,接受提尔泽帕提德治疗的参与者的比例显著降低了≥5% (79-83%).
- 胃肠道不良反应 (恶心,腹,吐) 是最常见的,但一般为轻度至中度.
结论
- 在肥胖和2型糖尿病的成年人中,每周服用10 mg和15 mg的提尔泽帕提德可显著且具有临床意义的减肥效果.
- 蒂尔泽帕提德的安全性与其他用于体重控制的基于隐形蛋白的疗法相似.
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