感染SARS-CoV-2的儿童的病毒持续性:当前的证据和未来的研究策略
Danilo Buonsenso1, Laura Martino2, Rosa Morello2
1Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Italy; Centro di Salute Globale, Università Cattolica del Sacro Cuore, Rome, Italy.
The Lancet. Microbe
|June 29, 2023
概括
在儿童中,SARS-CoV-2 RNA和抗原的持久性可以在系统上发生数周到数月,无论COVID-19的严重程度如何. 这一发现对儿童群体的后病毒综合征的理解和管理产生了影响.
科学领域:
- 病毒学 病毒学
- 儿童传染病 儿童传染病
- 免疫学 免疫学 免疫学
背景情况:
- 新出现的证据表明,在SARS-CoV-2感染后的成年人中,病毒持续存在.
- 了解SARS-CoV-2在儿童中的持续性对于管理潜在的长期健康后果至关重要.
- 儿科多系统炎症综合征和长期COVID-19需要进一步调查潜在的病毒机制.
研究的目的:
- 审查和分析有关SARS-CoV-2RNA或儿童抗原持久性的现有文献.
- 为了调查SARS-CoV-2在儿科病例中的系统传播和持续时间.
- 探索病毒持久性对理解和管理儿童后病毒综合征的影响.
主要方法:
- 在小儿解剖,活检或手术样本中检查SARS-CoV-2RNA或抗原检测的研究文献综述.
- 考虑疾病严重程度,多系统炎症综合征和长期COVID-19评估的数据分析.
- 综合了关于病毒持续时间和儿童系统传播的研究结果.
主要成果:
- 在儿童中发现的SARS-CoV-2RNA或抗原持久性,无论COVID-19的初始严重程度如何.
- 有证据表明,SARS-CoV-2在儿科患者中的系统传播.
- 在儿童中,病毒的持久性可以持续数周到数月.
结论:
- 在儿童中,SARS-CoV-2可以在系统上持续长时间,而不依赖于疾病的严重程度.
- 病毒在儿童中的持久性可能导致后病毒综合征,需要进一步的研究.
- 临床,药理和基础科学研究应该探索病毒的持久性,以改善儿科病毒后疾病的管理.
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