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Updated: Jul 25, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

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通过西塔利普丁和林纳利普丁向DPP4-RBD相互作用,可以提供潜在的宿主导疗法来对抗泛SARS-CoV-2感染

Shailendra Mani1, Anupamjeet Kaur2, Kamini Jakhar1

  • 1Translational Health Science and Technology Institute, Faridabad, India.

International journal of biological macromolecules
|June 29, 2023
PubMed
概括

这项研究表明,SARS-CoV-2除了使用ACE2外,还使用人类DPP4进入细胞. 像西塔格利普丁和林纳格利普丁这样的DPP4抑制剂阻断了这个过程,阻止了病毒的复制.

关键词:
ACE2-RBD相互作用,重定向治疗在DPP4-RBD复合体中.全型SARS-COV-2病毒的出现.

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