在 Behçet 综合征中治疗血管干扰的 Infliximab
Gulen Hatemi1, Nur Beyza Tukek2, Sinem Nihal Esatoglu1
1Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey; Behçet's Disease Research Center, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
在Behçet病例中,Infliximab有效治疗血管干扰.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 血管医学 血管医学
背景情况:
- 血管干扰在贝希特综合征 (BS) 中显著导致发病率和死亡率.
- 现有的免疫抑制疗法可能并不总是足以管理BS的血管并发症.
- 在这种特定患者群体中,因弗力西马布 (IFX) 的疗效和安全性需要进一步研究.
研究的目的:
- 评估infliximab (IFX) 在 Behçet综合征 (BS) 患者的疗效和安全性.
- 确定缓解率,并确定影响治疗结果的因素.
- 在这个队列中评估与IFX治疗相关的不良事件.
主要方法:
- 对127名 Behçet 综合征患者进行了回顾性审查,这些患者接受了infliximab (2004-2022) 治疗.
- 主要终点:6个月缓解,根据临床和成像标准和CRP水平定义.
- 复发定义为新的或复发的血管病变;通过不良事件和死亡率来评估安全性.
主要成果:
- 在第6个月观察到73%的缓解率,在第12个月观察到63%的缓解率.
- 与其他患者相比,肺动脉干扰和静脉血栓症患者的缓解率更高.
- 发生了4例死亡,14名患者因不良事件而停止服用IFX.
结论:
- 在 Behçet 综合征患者的血管干扰管理中,Infliximab 显示出显著的疗效.
- 治疗似乎有效,即使在耐传统免疫抑制剂和葡萄糖皮质类药物耐药的患者中.
- IFX为耐火性血管贝切特综合征提供了有价值的治疗选择,尽管安全监测至关重要.
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