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Updated: Jul 25, 2025

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
10:25

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology

Published on: November 22, 2024

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选择性deubiquitinaseUSP30抑制的结构前提是由小分子硫胺胺的抑制

Darragh P O'Brien1, Hannah B L Jones1, Franziska Guenther2

  • 1Target Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, Oxfordshire, UK.

Molecular & cellular proteomics : MCP
|June 29, 2023
PubMed
概括

抑制线粒体酶Ubiquitin特定蛋白酶30 (USP30) 可能治疗神经退行性疾病,如帕金森病. 研究人员阐明了小分子抑制剂如何与USP30结合,揭示了其未来药物开发的机制.

关键词:
帕金森病是帕金森病的一种.基于活动的蛋白质分析.必须有不同的激光.发现药物的发现.二交换质谱测量 质谱测量线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.分子对接模拟分子对接模拟小分子硫胺胺.结构 - 活动关系结构 - 活动关系无处不在的特异性蛋白酶30

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