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儿童短期接触多种金属混合物和线粒体DNA拷贝数:一个小组研究

Shirong Lv¹, Xuefeng Lai¹, Wenting Guo¹

¹Department of Occupational and Environmental Health, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

The Science of the total environment

|June 29, 2023

概括

短期接触金属混合物,特别是,和,与儿童的线粒体DNA拷贝数 (mtDNAcn) 的减少有关. 年龄较小的儿童,女孩,以及那些水果和蔬菜摄入量较低的儿童,表现出更高的易感性.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
儿科健康儿科健康

背景情况:

线粒体DNA拷贝数 (mtDNAcn) 是细胞健康的生物标志物.
关于儿童短期接触金属混合物和mtDNAcn.cn.的数据有限.
了解这些关联对于儿科环境健康至关重要.

研究的目的:

在健康的儿童中研究短期接触金属混合物和mtDNAcn之间的关联.
确定有助于mtDNAcn.cn变化的特定金属.
为了探索基于年龄,性别和饮食的差异敏感性.

主要方法:

一项小组研究涉及144名儿童 (年龄在4-12岁) 跨越三个季节.
每天收集23种金属的尿样和白细胞mtDNAcn.cn的血液样本.
应用线性混合效应 (LME) 模型,LASSO和加权定量总和 (WQS) 回归.

主要成果:

(Ni), (Mn) 和 (Sb) 独立地与mtDNAcn.cn.减少相关.
在Ni (滞后0),Mn和Sb (滞后2) 的1倍增加与分别减少8.74%,6.93%和3.98%的mtDNAcn相关.
金属混合物显示了与mtDNAcn的整体反向关联,并观察到显著的减少.

结论:

暴露于金属混合物与健康儿童mtDNAcn的减少有关.
Ni,Mn和Sb是这种关联的关键贡献者.
年龄较小的儿童,女孩以及摄入较少水果/蔬菜的人更容易受到伤害.

关键词:

它们是反的.是一种.金属混合物金属混合物线粒体DNA复制号码的复制号码尼克尔尼克尔是什么意思专家小组研究小组研究

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