相关实验视频

Updated: Jul 25, 2025

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Assessment of the Immunomodulatory Properties of Human Mesenchymal Stem Cells MSCs

Published on: December 24, 2015

生物灵感平台的应用,用于增强中细胞流体细胞的免疫调节功能

Ok-Hyeon Kim¹, Tae Jin Jeon², Young In So²

¹Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul, Korea.

International journal of stem cells

|June 29, 2023

概括

生物工程方法可以增强介质细胞 (MSCs) 免疫调节潜力. 通过生物机械刺激和生物物理线索控制干细胞利基微环境,可以提高MSC治疗的疗效.

科学领域:

生物医学工程生物医学工程
干细胞生物学干细胞生物学
免疫学免疫学免疫学

背景情况:

介酶体 stromal 细胞 (MSCs) 在再生医学中表现有前途,因为它们具有自我更新,多能性和膜功能.
MSCs的临床应用受到*in vivo*移植后功效降低的限制.
生物工程策略可以创造干细胞利基状的条件,以改善MSC功能.

研究的目的:

探索如何控制干细胞利基微环境可以最大限度地提高MSC的免疫调节潜力.
讨论生物机械刺激和生物物理线索在增强MSC治疗中的作用.

主要方法:

对专注于生物机械刺激 (剪切应力,水立压力,拉伸) 的研究进行审查.
对生物物理线索的分析,包括细胞外矩阵模拟基质.
研究干细胞利基微环境调制的研究.

主要成果:

生物力学力量和生物物理线索可以显著影响MSC行为.
优化干细胞微环境可以增强MSC的免疫调节功能.
这些方法提供了潜在的解决方案,以克服MSC治疗的局限性.

结论:

用生物机械和生物物理线索调节干细胞利基对于提高MSC疗效至关重要.
生物工程技术对推进基于MSC的疗法具有前景.
对干细胞利基工程的进一步研究可以释放MSCs的全部治疗潜力.

关键词:

生物力学力量生物力学力量生物物理的线索.免疫调节是一种免疫调节.介酶体 stromal 细胞 (MSCs) 是一种中介酶体细胞.

更多相关视频

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell MSC Spheroids Primed in 3-D Cultures Under Xeno-free Conditions

Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell MSC Spheroids Primed in 3-D Cultures Under Xeno-free Conditions

Published on: March 18, 2017

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases

Published on: September 1, 2017

相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...