在一次性预防队列中,量化COPD作为心脏病的风险因素
Laura C Maclagan1, Ruth Croxford1, Anna Chu1
1ICES, Toronto, ON, Canada.
The European respiratory journal
|June 29, 2023
概括
患有慢性阻塞性肺病 (COPD) 的人面临的重大心血管事件 (MACE) 的风险比没有COPD的人高25%. 这一发现凸显了在COPD患者群体中需要积极的心血管疾病预防策略.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- 慢性阻塞性肺病 (COPD) 是心血管疾病 (CVD) 的已知危险因素之一.
- 风险分层对初级心血管疾病预防至关重要,但COPD患者没有先前心血管疾病的真实心血管疾病风险尚未研究.
- 了解这种风险可以为COPD患者提供更好的心血管疾病管理策略.
研究的目的:
- 在被诊断患有COPD但没有心血管疾病史的大量现实人群中调查重大心血管不良事件 (MACE) 的风险.
- 量化COPD与MACE发生率之间的关联,包括急性心肌梗塞,中风和心血管死亡.
主要方法:
- 使用加拿大安大略省 (2008-2016) 的综合健康数据进行了一项回顾性人口队列研究.
- 该研究包括40岁以上没有心血管疾病史的个人,并比较了医生诊断的COPD和没有COPD的人.
- 使用顺序的因果特异性危险模型来确定MACE风险,并根据心脏风险因素和并发症进行调整.
主要成果:
- 这项研究分析了大约580万个人,其中152,125人被诊断患有COPD.
- 在调整了相关风险因素和并发症后,COPD患者的MACE发病率比没有COPD的人高出25% (危险比:1.25,95% CI:1.23-1.27).
结论:
- 医生诊断的COPD与以前没有心血管疾病的个人显著增加 (25%) 的重大心血管事件的可能性有关.
- 在COPD患者中,这种风险增加与糖尿病患者中观察到的风险相似.
- 这些发现强调了对COPD患者量身定制的更积极的初级心血管疾病预防策略的必要性.
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