长期成像随访从管理的骨髓瘤结核研究研究的管理
E George1, C MacPherson2, S Pruthi3
1From the Departments of Radiology and Biomedical Imaging (E.G., O.A.G.).
AJNR. American journal of neuroradiology
|June 29, 2023
概括
产前修复骨髓髓细胞导致更好的长期大脑发育. 这种手术改善了Chiari II形结果,并减少了与产后修复相比后脑异常.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 儿科手术 儿科手术
背景情况:
- 产前骨髓髓瘤修复显示了短期的好处,如减少头症和改善Chiari II形.
- 长期成像结果比较产前和产后修复需要进一步调查.
研究的目的:
- 为了评估长期 (学龄) 的脑成像发现,在接受产前与产后骨髓瘤修复的患者中.
- 为了比较两个手术组之间的Chiari II形特征的持久性和解决.
主要方法:
- 对来自"骨髓瘤结核病管理研究"的患者在学龄期脑部MRI成像的分析.
- 在66例产前和63例产后修复病例之间比较后和上突异常.
- 评估从胎儿到学龄期MRI成像发现的变化.
主要成果:
- 产前修复与正常的第四腹腔位置有关,并且在学龄时减少了后脑,小脑,直肠和脑干扭曲 (P < .01).
- 两组之间没有观察到突突异常的显著差异 (例如,体,旋转异常) (P > .05).
- 在产前修复组 (P < .02) 中,脑干扭曲,直肠,小脑/后脑的解决率更高.
结论:
- 产前骨髓髓瘤修复在与学校年龄的奇亚里II形相关的后腔成像中提供了持久的改善.
- 这些发现支持产前干预,以改善骨髓瘤瘤患者的长期神经结果.
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