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在患有代谢综合征的青少年中调查心血管风险参数

Ummugulsum Can¹, Sadinaz Akdu², Zafer Bağcı³

¹Department of Biochemistry, Konya City Hospital, Konya, Turkey.

Cardiology in the young

|June 29, 2023

概括

在患有代谢综合征的青少年中,血清folistatin (FST) 和与怀孕相关的血蛋白-A (PAPP-A) 水平升高. 这些生物标志物可能有助于诊断代谢综合征,并预防该群体未来的并发症.

科学领域:

内分泌学在内分泌学.
儿科内分泌学儿科内分泌学
代谢障碍代谢障碍代谢障碍

背景情况:

代谢综合征是一种多因素状况,与2型糖尿病和心血管疾病有关.
低度炎症是代谢综合征的一个特征.
青少年代谢综合征需要进一步调查潜在的诊断标志物.

研究的目的:

在患有代谢综合征的青少年中评估血清中follistatin (FST),妊娠相关血蛋白-A (PAPP-A) 和血小板/内皮细胞粘附分子-1 (PECAM-1) 的水平.
探索这些生物标志物在青少年代谢综合征诊断中的潜力.

主要方法:

一项病例控制研究,涉及43名患有代谢综合征的青少年和37名瘦身对照.
使用ELISA方法量化了FST,PAPP-A和PECAM-1的血清水平.
统计分析包括后勤回归来确定标记者的意义.

主要成果:

与对照人群相比,患有代谢综合征的青少年的血清FST和PAPP-A水平显著更高.
两组之间没有观察到血清PECAM-1水平的显著差异.
在代谢综合征组中,在FST和甘油三之间,以及PAPP-A和体重之间发现了积极的相关性.
福利斯塔丁在单变量和多变量逻辑回归分析中都显示出统计学意义.

结论:

血清FST和PAPP-A水平的升高与青少年的代谢综合征有显著的关联.
这些生物标志物有可能用于早期诊断青少年的代谢综合征.
使用FST和PAPP-A可能有助于预防与代谢综合征相关的长期并发症.

关键词:

代谢综合征是代谢综合征.里斯塔丁是一种里斯塔丁.血小板/内皮细胞粘附分子-1-1 与怀孕相关的血蛋白-A.

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