用磁共振成像R2*评估的卵巢内膜异位症中的铁沉积与卵巢功能相关
Shumin Yan1, Xiaoyu Dong1, DaWei Ding2
1Shandong Provincial Hospital, Shandong University, 324 Jingwuweiqi Road, Jinan City, Shandong Province, China, 250021; Cheeloo College of Medicine, Shandong University, 44 Wenhua West Road, Lixia District, Jinan City, Shandong Province, China, 250014; Gynecology Laboratory, Shandong Provincial Hospital, Jinan, Shandong Province, China, 250021.
Reproductive biomedicine online
|June 29, 2023
概括
在子宫内膜异位症患者中,铁过载会损害卵巢功能,这是MRI R2*测量结果表明的. 这种铁沉积与年轻女性的抗穆勒尔激素 (AMH) 水平有负相关性,表明卵巢储备减少.
科学领域:
- 生殖医学 生殖医学
- 医疗成像医学成像
- 内分泌学 在内分泌学.
背景情况:
- 子宫内膜异位症与卵巢功能受损有关.
- 卵巢组织中的铁沉积可能导致这种损伤.
研究的目的:
- 在子宫内膜异位症患者中调查卵巢铁沉积和卵巢储备之间的相关性.
- 探索磁共振成像 (MRI) R2*作为一种视觉评估铁过载及其对卵巢功能影响的方法的潜力.
主要方法:
- 使用MRI R2*来量化卵巢铁沉积在子宫内膜异位症患者和对照.
- 测量了血清抗穆勒尔激素 (AMH) 水平作为卵巢储备的标志物.
- 在不同组之间比较铁沉积和AMH水平.
- 在实验室中研究了铁对小鼠卵巢颗粒细胞中AMH分泌的影响.
主要成果:
- 与对照组相比,在子宫内膜异位症患者中观察到明显更高的铁沉积 (P < 0.0001) 和升高的R2*值.
- 在18-35岁的子宫内膜异位症患者的血清AMH水平和MRIR2*值之间发现了显著的负相关性 (rs = -0.6484,P < 0.0001).
- 在体外研究表明,随着铁暴露的增加,AMH的转录和分泌减少.
结论:
- 卵巢铁沉积,可通过MRI R2*量化,与子宫内膜异位症的卵巢功能受损有关.
- 核磁共振R2*可以作为由于铁过载而导致的卵巢功能障碍的视觉指标.
- 年轻子宫内膜异位症患者的AMH水平降低与卵巢铁的增加相关,这表明卵巢储备减少.
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