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草甘通过细胞衰老和脂质积累引起血管毒性
Jian Lu1, Cheng Zhang2, Weiguo Wang1
1Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Chemical research in toxicology
|June 29, 2023
概括
草甘 (GLY) 暴露会导致人类大动脉细胞的细胞衰老和DNA损伤. 这种除草剂可能会增加动脉样硬化风险,特别是在职业暴露的个体中.
科学领域:
- 毒理学 毒理学 毒理学
- 心血管生物学 心血管生物学
- 细胞生物学 细胞生物学
背景情况:
- 草甘 (GLY) 是一种广泛使用的除草剂,人们越来越关注其对健康的风险.
- 目前尚不清楚GLY对血管的潜在毒性影响,特别是在职业暴露的人群中.
研究的目的:
- 研究GLY对人类大动脉血管光滑肌细胞 (HAVSMC) 的血管毒性影响.
- 探索GLY暴露和动脉样硬化的发展之间的关系.
主要方法:
- 评估了GLY对HAVMC形态,衰老标志物 (β-galactosidase,p53,p21,p16) 和细胞损伤 (ROS,DNA,线粒体) 的影响.
- 研究了Nrf2-Keap1通路的激活,以应对GLY诱导的氧化应激.
- 利用斑马鱼模型评估GLY的体内血管效应,包括失脂症和巨细胞招募.
主要成果:
- 在HAVSMC中,GLY诱导了细胞衰老,其特征是形态变化和衰老标志物增加.
- 在HAVSMC中,GLY暴露导致了氧化应激,DNA损伤和线粒体功能障碍.
- 在体内,斑马鱼的GLY暴露导致脂质不良和血管系统中巨细胞透的增加.
结论:
- 草甘通过细胞衰老和氧化应激途径诱导血管毒性.
- 暴露于GLY与脂质不良和血管炎症有关,这表明它是动脉样硬化的潜在危险因素.
- 这些发现强调了需要谨慎对待慢性职业暴露于草甘的个体心血管风险的需要.
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