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Updated: Jul 25, 2025

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剖析MBD2异型和域在细胞分化过程中调节NuRD复杂功能中的作用

Nina Schmolka1,2, Ino D Karemaker1, Richard Cardoso da Silva1,3

  • 1Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.

Nature communications
|June 29, 2023
PubMed
概括

甲基-CpG结合域 (MBD) 蛋白质MBD2和MBD3是通过NuRD复合体进行细胞分化的关键. 特定的MBD2异型可以取代MBD3,而MBD2b完全挽救了MBd3缺陷的干细胞分化.

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