唾液生物标志物:用于诊断慢性炎症的新型非侵入性工具
Paola Dongiovanni1, Marica Meroni1, Sara Casati2
1Medicine and Metabolic Diseases, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
International journal of oral science
|June 29, 2023
概括
唾液分析提供了一种非侵入性方法,用于检测与2型糖尿病等慢性疾病相关的炎症生物标志物. 本综述探讨了使用唾液用于早期诊断和治疗监测,可能取代传统的血液检测.
科学领域:
- 生物标志物发现发现
- 翻译医学是一种翻译医学.
- 炎症研究 炎症研究
背景情况:
- 慢性轻度炎症之前的2型糖尿病,肥胖,心脏病和癌症.
- 唾液生物标记物,包括急性阶段蛋白 (APP),细胞因子和氧化应激介质,反映系统性炎症.
- 唾液为生物标志物检测提供了一种非侵入性的,具有成本效益的替代方案,因为它的可访问性和与血清度的相关性.
研究的目的:
- 审查使用唾液检测炎症生物标志物的优点和挑战.
- 讨论唾液生物标志物发现的标准和新技术.
- 探索基于唾液的诊断潜力,用于具有炎症成分的慢性疾病.
主要方法:
- 审查关于唾液生物标志物分析的现有文献.
- 唾液收集和储存程序的描述.
- 评估标准测量技术和新的策略,如生物传感器.
主要成果:
- 唾液含有各种与血清水平相关的炎症媒介.
- 非侵入式的唾液采集是可行的,并且具有成本效益.
- 先进的技术,包括生物传感器,显示了增强的唾液生物标志物检测的希望.
结论:
- 唾液作为慢性炎症疾病的诊断液具有显著的潜力.
- 对唾液生物标志物和检测技术的进一步研究可以改善患者的护理.
- 基于唾液的诊断可能提供一种不那么侵入性的,更容易获得的替代传统方法.
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