相关实验视频

Updated: Jul 25, 2025

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

超急性黄蜂毒素免疫治疗中的时间依赖性细胞因子变化

W Urbańska¹, L Szymański², M Ciepelak³

¹Department of Infectious Diseases and Allergology, Military Institute of Medicine, National Research Institute, Szaserów 128, 04-141, Warsaw, Poland.

Scientific reports

|June 29, 2023

概括

对毒素过敏的毒素免疫疗法 (VIT) 显示IL-12,IL-9和TGF-β的增加. 这些细胞因子表明向Th1和调节性T细胞通路的转变,有助于脱敏.

科学领域:

免疫学免疫学免疫学
过敏研究研究过敏
治疗策略治疗策略

背景情况:

毒药免疫疗法 (VIT) 旨在修改对毒药过敏原的免疫反应.
之前的研究表明,在VIT期间,与IL-2和IFN-γ生产发生了Th2到Th1的转变.
了解VIT后的长期免疫变化至关重要.

研究的目的:

为了调查VIT后的血清细胞因子概况,以检测黄蜂毒素过敏.
探索潜在的新免疫路径,参与VIT诱导的脱敏.
在VIT的24周内评估30种细胞因子的变化.

主要方法:

在多个时间点测量了61名患者 (43名VIT,18名对照) 的血清细胞因子水平.
患者对黄蜂毒素过敏.
分析侧重于30种不同的细胞因子,包括IL-2,IFN-γ,IL-12,IL-9和TGF-β.

主要成果:

在VIT后没有观察到IL-2和IFN-γ水平的显著变化.
发现IL-12度显著增加,支持Th1通路的参与.
高水平的IL-9和TGF-β表明在调节性T细胞生成中起作用.

结论:

对毒素过敏的VIT可能涉及IL-12介导的Th1通路激活.
增加IL-9和TGF-β表明调节性T细胞在VIT中的潜在参与.
需要进一步的研究,以充分阐明VIT的机制.

更多相关视频

Author Spotlight: Efficient Venom Extraction Method from Trichogramma Parasitoid Wasps

Author Spotlight: Efficient Venom Extraction Method from Trichogramma Parasitoid Wasps

Published on: October 6, 2023

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

相关概念视频

Allergic Reactions

Allergic Reactions

Cross-reactivity

Cross-reactivity

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

Allergic Drug Reactions

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...