对调查问卷的项目非响应行为模式是系统的,并与遗传位置相关
Gianmarco Mignogna1,2,3,4, Caitlin E Carey1,4,5, Robbee Wedow6,7,8,9,10
1Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Nature human behaviour
|June 29, 2023
概括
调查中的项目不响应,例如"宁愿不回答" (PNA) 和"我不知道" (IDK),预测了未来的不响应,并且与教育,健康和收入有遗传相关性. 这些遗传联系可能会影响研究结果,特别是在全基因组关联研究中.
科学领域:
- 遗传学 是一个遗传学.
- 行为科学 行为科学
- 流行病学 流行病学
背景情况:
- 调查响应对于社会和行为研究至关重要.
- 项不回答,包括"宁愿不回答" (PNA) 和"我不知道" (IDK) 答案,是常见的,可能妨碍研究解释和概括性.
- 了解影响非响应的因素对于提高数据质量至关重要.
研究的目的:
- 在一个大型队列中检查项目非响应行为 (英国生物库).
- 通过全基因组关联研究 (GWAS) 调查非反应的遗传基础.
- 评估基因和表型研究中因非响应引入的潜在偏见.
主要方法:
- 分析的项目是360,628名英国生物银行参与者的109个问卷项目未得到回答.
- 计算PNA和IDK反应的表型因子得分.
- 对PNA和IDK因素进行了GWAS,并检查了它们与教育,健康和收入的遗传相关性.
主要成果:
- 在后续调查中,PNA和IDK得分预测了参与者的非响应.
- PNA和IDK在遗传学上相互高度相关 (rg=0.73).
- 无论是PNA还是IDK,都显示出与教育 (负面),健康 (正面) 和收入 (负面) 有显著的遗传相关性,同时也观察到独特的遗传关联.
结论:
- 像PNA和IDK这样的物品非响应行为受到遗传因素的影响.
- 这些遗传相关性可以在检查与非响应相关的特征的研究中引入偏见,特别是GWAS.
- 研究人员在解释研究结果时应考虑项目非响应及其遗传基础的影响.
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