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在年轻成年人中,局部性牙周炎的严重程度与动脉内膜介质厚度相关:CHIEF动脉样硬化研究

Kun-Zhe Tsai^1,2,3, Wei-Chun Huang⁴, Yun-Chen Chang⁵

¹Department of Internal Medicine, Hualien Armed Forces General Hospital, No. 100, Jinfeng St., Hualien City, 970, Taiwan.

Scientific reports

|June 29, 2023

概括

严重的牙周炎与年轻成年人动脉内膜介质厚度 (cIMT) 的增加有关. 这突显了炎症.

科学领域:

心血管健康心血管健康
牙周病学牙周病学
公共卫生公共卫生

背景情况:

亚临床动脉样硬化症是心血管疾病的前体,在年轻人群中越来越多地被发现.
牙周炎是一种慢性炎症性疾病,已与全身性疾病有关,但其在早期动脉样硬化中的作用需要进一步调查.

研究的目的:

在年轻成年人中调查牙周炎严重程度和亚临床动脉样硬化之间的关联,通过动脉内膜介质厚度 (cIMT) 测量.
确定该人群中增加cIMT的独立风险因素.

主要方法:

一项涉及486名台湾非糖尿病军人的横截面研究.
通过超声波评估的动脉内心介质厚度 (cIMT).
牙周炎的严重程度使用2017年美国/欧洲共识标准进行分类.
统计分析包括ANCOVA和多重物流回归,以潜在的混因素进行调整.

主要成果:

随着牙周炎的进展阶段 (p < 0.01),观察到平均cIMT的显著增加.
在牙周炎严重程度 (I-III阶段) 和cIMT最高五分位数 (≥0.8毫米) 之间发现了剂量反应关系.
增加的白细胞计数 (≥ 7.6 × 103 /μL) 独立地与增加的cIMT相关 (OR 1.86;95% CI 1.11-3.12).

结论:

严重的牙周炎和白细胞计数升高是年轻成年人cIMT增加的独立危险因素.
炎症在亚临床动脉样硬化的发展中起着至关重要的作用.
这些发现强调了管理牙周健康的重要性,以减轻心血管风险.

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