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超重和肥胖儿童的血小板指数
1Istinye State Hospital, Istinye Street No. 98, Sariyer, Istanbul, Turkey. deryakaly@hotmail.com.
European journal of pediatrics
|June 29, 2023
概括
血小板指数,如血小板计数 (PLT) 和血小板克里特 (PCT),在肥胖,超重和正常体重儿童之间存在显著差异. 肥胖儿童的PLT和PCT比率较高,MPV/PLT和PDW/PLT比率较低,特别是在胰岛素抵抗方面.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 血液学 血液学 血液学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖与慢性低度炎症有关.
- 血小板对于炎症,免疫和心血管健康至关重要.
研究的目的:
- 调查血小板指数与儿童肥胖之间的关联.
- 探索胰岛素抵抗如何影响这些关联.
主要方法:
- 190名肥胖/超重儿童和100名正常体重儿童的血小板指数 (PLT,PCT,MPV,PDW和比率) 的比较.
- 根据体重状况和胰岛素抵抗 (IR) 的存在,分析了差异.
主要成果:
- 与超重和正常体重组相比,肥胖儿童的PLT和PCT显著更高.
- 肥胖儿童的MPV/PLT和PDW/PLT比率较低.
- 患有肥胖和IR的儿童比没有IR的儿童有更高的PLT和更低的MPV/PLT和PDW/PLT比率.
结论:
- 血小板指数,特别是PLT,PCT,MPV/PLT和PDW/PLT,在儿童的体重类别之间显示出显著的差异.
- 这些血小板标志物可以作为儿童肥胖和相关胰岛素抵抗的指标.
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