结肠癌切除后的解肠道泄漏风险因素:系统性审查和元分析
Juan He1, Mei He2, Ji-Hong Tang1
1College of Nursing, Chengdu Medical College, Chengdu, Sichuan, People's Republic of China.
Langenbeck's archives of surgery
|June 29, 2023
概括
结肠癌手术后的静脉漏与男性性别,更高的BMI,糖尿病,肺部疾病以及紧急或开放手术有关. 年龄和心血管疾病需要进一步调查作为潜在的风险因素.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 流行病学 流行病学
背景情况:
- 在结肠癌切除后,解肠漏仍然是一个显著的并发症,增加了患者的发病率和死亡率.
- 尽管外科手术技术取得了进步,但有效的减轻这种风险的策略至关重要.
研究的目的:
- 系统地审查和识别与结肠癌手术后的静脉漏相关的关键风险因素.
- 为临床医生提供基于证据的指导,以减少静脉漏的发生率.
主要方法:
- 对多个数据库 (PubMed,Ovid,Web of Science,Cochrane) 进行了全面的系统审查.
- 包括的研究是截至2022年3月31日发布的横截面,队列或病例控制设计.
- 分析了包括115,462名患者在内的16项队列研究的数据.
主要成果:
- 截面泄漏的总发病率为3.4% (3959例).
- 确定的重大风险因素包括男性性别,高BMI,糖尿病,肺部疾病,更高的麻醉ASA得分,紧急手术,开放手术和特定的切除类型.
- 在这项分析中,年龄和心血管疾病与静脉泄漏没有统计学上显著的关联.
结论:
- 男性性别,肥胖 (BMI),肺部疾病,麻醉风险 (ASA分数),紧急手术,开放式手术和切除类型是确认的道泄漏的风险因素.
- 需要进一步的研究来澄清年龄和心血管疾病在结肠癌手术后手术后的静脉泄漏中的作用.
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