怀孕时间和累积暴露与黑色素瘤生存时间之间的关联
Sarah B Bateni1,2,3, Rinku Sutradhar4, Karl Everett5
1Division of General Surgery, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Annals of surgical oncology
|June 29, 2023
概括
怀孕似乎不会对生育年龄妇女的黑色素瘤预后产生负面影响. 这项研究发现,黑色素瘤特异性存活率或与妊娠状态相关的总生存率没有显著差异.
科学领域:
- 在瘤学瘤学.
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 黑色素瘤是年轻女性中流行的一种癌症.
- 怀孕对黑色素瘤结果的影响需要调查.
研究的目的:
- 评估怀孕与生育年龄的女性黑色素瘤患者的存活率之间的关联.
- 为了确定怀孕是否会影响黑色素瘤的预后.
主要方法:
- 在加拿大安大略省,对1312名被诊断患有黑色素瘤的18-45岁妇女进行了人口层次的回顾性队列研究 (2007-2017年).
- 根据与黑色素瘤诊断相对的怀孕状况对患者的分类:前,相关和后.
- 考克斯比例危险模型用于分析黑色素瘤特异性生存率 (MSS) 和整体生存率 (OS).
主要成果:
- 怀孕状态 (黑色素瘤前,相关或后) 和黑色素瘤特异性存活率 (MSS) 之间没有发现显著的关联.
- 总生存率 (OS) 在妊娠状态组之间也没有显著差异.
- 累计怀孕周并没有对MSS或OS产生显著影响.
结论:
- 在被诊断患有黑色素瘤的女性患者中,怀孕与更糟糕的预后无关.
- 研究结果表明,怀孕不会对患有黑色素瘤的女性的生存结果产生不利影响.
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