儿童和青少年的SARS-CoV-2感染和肺结核:一个病例控制研究
Jeremi Swanepoel1,2, Marieke M van der Zalm3, Wolfgang Preiser4
1Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa. jswan@sun.ac.za.
BMC infectious diseases
|June 29, 2023
概括
这项研究没有发现先前严重急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 感染和儿童肺结核 (TB) 风险之间的强烈联系. 然而,较高的SARS-CoV-2抗体水平可能与结核病风险增加有关.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- COVID-19大流行对全球结核病 (TB) 流行病的影响是显著的.
- 关于SARS-CoV-2和结核病之间的相互作用的证据有限,特别是在儿童群体中.
- 这项研究调查了先前的SARS-CoV-2感染与儿童和青少年结核病风险之间的关系.
研究的目的:
- 评估之前的SARS-CoV-2感染与儿童和青少年患结核病的风险之间的关联.
- 在儿科队列中探索SARS-CoV-2和结核病之间的潜在相互作用.
主要方法:
- 在南非开普敦进行了一项无与伦比的病例控制研究.
- 包括64名肺结核儿童和青少年和99名对照组 (年龄<20岁).
- 评估了SARS-CoV-2抗高峰IgG水平,使用定量测定和结核病估计几率比率 (ORs).
主要成果:
- 在SARS-CoV-2 IgG 血清阳性和血清阴性个体 (aOR 0.51) 之间没有发现肺结核几率的统计学上显著差异.
- 在血清阳性个体中,与对照人群相比,结核病患者的基线IgG标位较高 (p=0.04).
- 在最高三位数中IgG标位的个体患肺结核的可能性更高 (OR:4.00;p=0.03).
结论:
- 该研究没有找到令人信服的证据,表明SARS-CoV-2血清阳性与儿童和青少年随后的肺结核病有关.
- 在SARS-CoV-2的IgG反应和肺结核之间的关系值得进一步调查.
- 需要进行未来的前性研究,以澄清儿科患者中M.结核病和SARS-CoV-2感染之间的相互作用.
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