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探讨血清纤维细胞生长因子-21水平与萨科佩尼亚之间的相关性:系统性审查和元分析
Hao Liu1, Xia He2, Xiao-Yan Deng3
1School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
BMC musculoskeletal disorders
|June 29, 2023
概括
这次审查没有发现强有力的证据将纤维细胞生长因子21 (FGF-21) 水平与皮症联系起来. 尽管FGF-21对肌肉健康起着重要作用,但它并不是诊断肉症的可靠生物标志物.
科学领域:
- 内分泌学和新陈代谢学
- 老年学是一门学科.
- 肌肉生理学 肌肉生理学
背景情况:
- 纤维细胞生长因子21 (FGF-21) 涉及骨肌肉细胞生长和新陈代谢.
- 标志着肌肉质量和力量下降的萨尔科佩尼亚,影响着老年人群.
- 了解影响肉类的因素对于公共卫生至关重要.
研究的目的:
- 系统地审查有关FGF-21水平与肉症之间的关系的现有证据.
- 为了确定与sarcopenia相关的潜在影响因素.
- 评估FGF-21作为肉症的潜在生物标志物.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在主要数据库 (PubMed,EMBASE,Web of Science,Scopus,中国数据库) 进行全面的文献搜索.
- 使用Review Manager 5.4进行的五项研究 (625例) 的元分析,评估了BMI,握力和血清FGF21水平.
主要成果:
- 萨尔科佩尼亚组的BMI和握力显著降低.
- 在萨科佩尼亚和非萨科佩尼亚组之间,血清FGF21水平没有统计学上显著的差异.
- 在萨科佩尼亚发病和血清FGF21水平之间没有发现强烈的相关性.
结论:
- 目前的证据不支持FGF-21升高和肉症之间的直接关系.
- FGF-21不是一种令人信服的生物或诊断标志物用于萨科佩尼亚.
- 现有的萨科佩尼亚诊断标准可能需要重新评估,以与临床实践保持一致.
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