在热带适应性公牛的公牛生产和生育特征的基因组范围的关联

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Wei Liang Andre Tan¹, Laercio Ribeiro Porto Neto², Antonio Reverter²

¹School of Chemistry and Molecular Biosciences, The University of Queensland, Chemistry Bld, 68 Cooper Rd, Brisbane City, QLD, 4072, Australia. weiliangandre.tan@uq.net.au.

|June 29, 2023

概括

对热带适应性公牛的基因组分析确定了与生育和生产特征相关的遗传变异. 这项研究强调了将X染色体纳入未来遗传研究以改善公牛繁殖的重要性.

科学领域:

动物遗传学动物遗传学
畜牧业生产畜牧业生产
基因组分析基因组分析

背景情况:

男性生育遗传学是复杂的,并影响畜牧业的经济学.
低生育的公牛降低了生产效率,增加了管理成本.
关键的生育特征,如阴囊周长和精液质量,对于公牛的选择至关重要.

研究的目的:

对七种公牛生产和生育特征进行全基因组关联分析.
识别影响多品种群体中的公牛生育能力和生产的遗传变异和候选基因.
调查序列级数据在理解这些复杂特征中的作用.

主要方法:

全基因组关联研究 (GWAS) 使用对6422头热带适应公牛的序列级数据.
分析了七个特征:体重,身体状况得分,阴囊周长,阴囊得分和三个精液质量参数 (PNS,MP,PD).
混合模型方法采用多品种基因组关系矩阵和Bonferroni对显著性的纠正.

主要成果:

确定了与公牛生育和生产特征相关的显著遗传变异和候选基因.
在Bos taurus自体 (BTA) 5上发现了关于阴囊周长,阴囊和精液质量特征 (PNS,PD,MP) 的关联.
染色体X与阴囊周长,PNS和PD有显著的关联,这强调了它对男性生育能力的重要性.

结论:

这项研究有助于识别导致公牛生育和生产特征的分子机制.
强调在基因组分析中包括X染色体的关键需要,以获得全面的理解.
未来的研究将专注于下游分析,以调查潜在的致病变体和基因.

关键词:

雄牛的生育能力雄牛的生育能力全基因组协会研究研究.定量性特征位置 (loci loci) 是一个定量性特征位置.在序列级别的级别.

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