不基于胰岛素的胰岛素抵抗指数与经过皮肤冠状动脉干预的患者的心血管事件之间的关联:一项回顾性研究
Zenglei Zhang1, Lin Zhao1, Yiting Lu1
1Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167, Beilishi Road, Xicheng District, Beijing, 100037, China.
Cardiovascular diabetology
|June 29, 2023
概括
像METS-IR和TyG-BMI这样的胰岛素耐药性 (IR) 指数可以预测接受PCI的老年人和女性患者的心血管事件. 虽然没有改善基本风险模型,但METS-IR对风险分层有很大的希望.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
- 生物标志物 生物标志物
背景情况:
- 胰岛素耐药性 (IR) 与心血管疾病 (CVD) 的病原发生有关.
- 不基于胰岛素的IR替代物如METS-IR,TG/HDL-C,TyG和TyG-BMI正在出现.
- 它们对皮肤穿刺冠状动脉干预 (PCI) 后心血管结果的预测价值需要进一步调查.
研究的目的:
- 调查非胰岛素基础的IR指数与主要心脏和脑血管不良事件 (MACCEs) 之间的关联.
- 评估这些IR指数在接受PCI的患者中的预测性表现.
主要方法:
- 分析了接受PCI的2533名患者队列,其中1461人用于相关性研究.
- 使用多变量逻辑回归和受限立方线 (RCS).
- 对总人口和特定子组 (年龄,性别) 进行了分析.
主要成果:
- 在总人口中,IR指数和MACCE之间没有发现显著的关联.
- 亚组分析显示,在老年人 (TyG-BMI,METS-IR) 和女性患者 (所有指数) 中存在显著的关联.
- METS-IR显示,老年人和女性患者的MACCE与线性关系,但没有一个指数改善了基本风险模型的预测能力.
结论:
- 四个IR指数与女性患者的MACCE相关;老年患者的TyG-BMI和METS-IR.
- METS-IR是二次MACCE预防和PCI患者风险分层的一个有希望的指数.
- 尽管存在关联,但这些指数并没有提高标准风险模型的预测能力.
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