慢性鼻炎和免疫球蛋白缺乏症患者的内镜鼻手术结果
Shireen Samargandy1, Elysia Grose1, Jonathan Yip1,2
1Division of Rhinology, Department of Otolaryngology - Head and Neck Surgery, St. Michael's Hospital, Unity Health Toronto, University of Toronto, 30 Bond Street, 8 Cardinal Carter, Toronto, ON, M5B 1W8, Canada.
概括
针对慢性鼻炎 (CRS) 进行内镜鼻手术 (ESS) 的免疫球蛋白缺乏症 (ID) 患者经历了显著的症状改善. 然而,在这个人群中,更高的修复手术率可能会发生.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
背景情况:
- 患有慢性鼻炎 (CRS) 和免疫球蛋白缺乏症 (ID) 的患者经常出现严重的鼻疾病.
- 在ID患者中,CRS的外科治疗是常见的,但结果数据有限.
- 需要在ID患者中建立CRS治疗算法.
研究的目的:
- 为了评估内镜鼻手术 (ESS) 在ID患者的结果.
- 用SNOT-22得分来评估疾病特异性生活质量变化.
- 为了确定在这个患者群体中是否需要修复手术.
主要方法:
- 一项病例控制研究比较了ID的成年患者和接受ESS进行CRS的健康对照.
- 根据年龄,性别,CRS表型和手术前的Lund-Mackay分数,患者被匹配.
- 分析了修复手术率,修复时间和SNOT-22得分变化.
主要成果:
- 13名ID患者与26名对照人群进行了匹配.
- 修复手术的发生率在ID患者中为31%,在对照组中为12% (p>0.05).
- 两组都显示出临床上有意义的SNOT-22得分降低,手术后两组之间没有显著差异.
结论:
- 在ID和CRS患者中,ESS提供了临床上有意义的症状改善.
- 与免疫能力高的人相比,ID患者可能会经历更高的修复手术率.
- 需要对更大,同质群体进行进一步的研究,以澄清ESS对ID患者的影响.
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