无阿片类麻醉与包括阿片类麻醉用于乳腺癌手术:一项回顾性研究
Pia Di Benedetto1, Massimiliano Pelli1, Chiara Loffredo1
1Anesthesia and Intensive Care Medicine, Department of Clinical and Surgical Translational Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1035, 00189, Rome, Italy.
与包括阿片类药物在内的麻醉 (OIA) 相比,使用胺,和克洛尼丁的多式无阿片类麻醉 (OFA) 有效地减少了经术后的疼痛和乳腺癌四角切除术后的恶心/吐. 患者的满意度在各组之间仍然可比.
科学领域:
- 麻醉学 麻醉学
- 在瘤学瘤学.
- 疼痛管理 疼痛管理
背景情况:
- 乳腺癌手术的阿片类药物含麻醉 (OIA) 与恶心和吐等不良反应有关.
- 无阿片类药物多式麻醉 (OFA) 旨在减轻这些副作用.
- 四角切除术是一种常见的乳腺癌手术.
研究的目的:
- 评估OFA使用胺,和克洛尼丁在治疗术后疼痛方面的疗效.
- 评估OFA在四角切除术后减少术后恶心和吐 (PONV) 的影响.
- 为了比较OFA和OIA组之间的患者满意度.
主要方法:
- 回顾性单中心研究,涉及89名接受四角切除术的患者.
- 患者被划分为OFA (酸盐,酸盐) 和OIA (雷米芬坦尼尔) 组.
- 术后疼痛,PONV发病率和患者满意度 (QoR-40) 进行了比较.
主要成果:
- 在手术后的多个时间点 (30分,6,12,24小时) 中,OFA组的疼痛得分明显较低.
- 在OFA组中,所需的救援止痛剂剂量 (甲) 较少.
- 与OIA组相比,OFA组的PONV发病率明显降低 (p <0.05).与OIA组相比,OFA组的PONV发病率显著降低 (p <0.05).
结论:
- 胺,和克洛尼丁的组合在四角切除术后提供了卓越的术后疼痛控制.
- 与传统的阿片类药物止痛药相比,OFA显著降低了PONV的发生率.
- 在两种麻醉方法中,患者满意度相似.
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