德克萨米他和术后疼痛缓解在微创胸部手术:一个回顾性队列研究
Marzia Umari1, Giacomo Paluzzano2, Matteo Stella2
1Department of Anesthesia and Intensive Care, Azienda Sanitaria Universitaria Giuliano-Isontina, Cattinara University Hospital, Trieste, Italy. m.marzia.umari@gmail.com.
Journal of anesthesia, analgesia and critical care
|June 29, 2023
概括
德克萨米他并没有显著减少胸部手术患者的吗啡使用,但它是安全的. 它可能有助于控制疼痛,作为多模式麻醉方法的一部分,减少了救援疼痛治疗的需要.
科学领域:
- 麻醉学 麻醉学
- 胸部外科手术 胸部外科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 德克萨米他用于术后恶心和吐 (PONV),可能有助于术后疼痛缓解.
- 它在微创胸部手术中作为止痛辅助剂的作用需要进一步评估.
研究的目的:
- 评估德克萨米他作为缓解疼痛的辅助剂在微创胸部手术中的有效性.
- 关键结局包括吗啡消耗,疼痛控制 (NRS),血糖变化,PONV和手术伤口感染.
主要方法:
- 一项回顾性队列研究,对70名通过迷你胸切除术或VATS进行选择性胸部手术 (叶切除术,细分切除术,切除术) 的患者进行.
- 患者接受了标准化的局部麻醉和阿片类药物;46人接受了外科手术期间的德克萨米他.
主要成果:
- 两组之间24小时吗啡消耗或术后疼痛得分没有显著差异.
- 不接受德克萨米他治疗的患者需要更频繁的救援止痛 (p=0.01).
- 在德克萨米他组中,术后血糖暂时较高,而在低血糖治疗需要方面没有差异. 后遗传肺炎病毒和感染率相似.
结论:
- 手术前的德克萨米他在微创胸部手术中没有显著降低吗啡消耗.
- 在这些患者的多模式麻醉策略中,甲似乎是安全和有益的.
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