大量的红血细胞疏散对健康捐赠者的心血管功能的影响
Qiang Chen1, Guan Yi Chen2, Jian Mei Chen3
1Department of Cardiology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, P.R. China.
European journal of clinical investigation
|June 29, 2023
概括
红血细胞 (RBC) 疏散使得与全血献血相比,每次献血可以收集更多的红血细胞体积. 这种高效和安全的方法没有对健康男性志愿者的心血管功能产生负面影响.
科学领域:
- 输血医学 输血医学
- 血液学 血液学 血液学
- 心血管生理学心血管生理学
背景情况:
- 在中国,对输血的需求日益增加,需要提高献血效率.
- 红血细胞 (RBC) 疏散被探索为增加每次捐赠的红血细胞收集量的一种方法.
- 试点研究探讨了增强的红细胞异位的安全性和可靠性.
研究的目的:
- 为了评估通过分泌法收集大量红细胞的安全性和有效性.
- 为了比较红细胞分离和传统全血献血之间的心血管功能.
主要方法:
- 32名健康的男性被随机分配到红细胞分离 (RA) 和全血 (WB) 献血组 (每组n=16).
- 风湿性关节炎组捐赠了个性化的红细胞体积;WB组捐赠了400毫升.
- 通过实验室检测,心声学和心肺检测,在8周内评估心血管功能.
主要成果:
- 风湿性关节炎组捐赠的红细胞显著多 (627.25毫升) 比WB组 (175.28毫升) (p<0.05).
- 在不同组之间或随着时间的推移,心脏生物标志物 (NT-proBNP,hs-TnT,CK-MB) 没有显著变化.
- 在整个研究期间,心声图和心肺功能在两组中保持稳定.
结论:
- 红细胞分泌是一种高效和安全的方法,可以在一次捐献中收集更多的红细胞.
- 与传统的全血献血相比,这种方法不会显著改变心血管功能.
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