铜的癌症干细胞活动(II) -与硫胺基的烯酸胺复合体与烯酸硫胺基组的复合体
Karampal Singh1, Joshua Northcote-Smith1, Kuldip Singh1
1School of Chemistry, University of Leicester, Leicester LE1 7RH, UK. k.suntharalingam@leicester.ac.uk.
Dalton transactions (Cambridge, England : 2003)
|June 30, 2023
概括
新的铜 (II) - 特皮里丁复合物显示出强大的抗癌活性. 综合体1通过产生反应性氧物种 (ROS),有效地向乳腺癌干细胞 (CSC),其性能优于现有的治疗方法.
科学领域:
- 无机化学 无机化学
- 药用化学 医学化学
- 癌症生物学 癌症生物学
背景情况:
- 铜II) - 特皮里丁复合物可以产生活性氧物种 (ROS) 并诱导癌细胞死亡.
- 癌症干细胞 (CSCs) 是瘤生长和转移的关键驱动因素,代表了一个关键的治疗点.
研究的目的:
- 为了合成和表征新型的铜(II) - - 特皮里丁复合物与酸硫胺基.
- 评估这些新型综合体的抗乳腺癌干细胞 (CSC) 特性.
主要方法:
- 合成和表征五个铜 (II) - 胺复合物.
- 评估生物相关溶液 (PBS,细胞培养基) 中的复杂稳定性.
- 使用乳球形成试验对抗CSC活性的评估和与已知药物 (沙利诺米辛,西斯普拉丁) 的比较.
- 机理学研究包括细胞吸收,ROS生成,内质网膜压力诱导和亡触发.
主要成果:
- 所有合成的铜 (II) - 胺复合体都表现出扭曲的正方形金字塔几何形状和生物介质中的稳定性.
- 综合体1,具有p-toluene sulfonamide组,与沙利诺和西斯相比,对乳腺CSC的效果是6-8倍.
- 综合体1有效地减少了哺乳层的形成,大小和生存能力.
- 机理学研究证实了乳腺CSC吸收复合体1,细胞内ROS生成,ER应激诱导和亡触发.
结论:
- 这项研究是首次对铜(II) - 特皮里丁复合物的抗乳房CSC特性进行研究.
- 铜 (II) - 胺复合体1显示显著的希望作为一种新的治疗药物向乳腺癌干细胞.
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