在标准肺炎球菌疫苗接种系列后的非保护性免疫力被确定为儿童难治耳鼻喉疾病的潜在贡献风险因素
Caroline A Bonaventure1, Adele K Evans1,2
1Department of Pediatric Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
The Annals of otology, rhinology, and laryngology
|June 30, 2023
概括
患有耐火性耳部感染的儿童肺炎球菌疫苗反应不足可能表明潜在的免疫缺陷. 进一步的测试可以揭示这些条件,以便更好地诊断和治疗.
科学领域:
- 儿童传染病 儿童传染病
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 在儿童中,耐火耳鼻喉感染的管理可能具有挑战性.
- 标准肺炎球菌疫苗 (PCV) 旨在预防感染,但可能会在一些人中失败.
研究的目的:
- 调查儿科患者的肺炎球菌疫苗接种所赋予的免疫力和耐火耳鼻喉感染之间的联系.
- 确定当疫苗接种未能提供保护性免疫力时可能出现的潜在疾病.
主要方法:
- 儿科患者 (0-21岁) 具有特定耳鼻喉诊断的回顾性病例系列 (2013-2021年).
- 对疫苗接种后的肺炎球菌抗体标位 (PCV 7或13) 和对后续疫苗接种的反应 (PPSV) 的分析.
- 对诊断和疫苗接种史的电子医疗记录的审查.
主要成果:
- 在再接种疫苗之前,只有27.0%的受试者具有保护性抗体标位.
- 在肺炎球菌多糖疫苗 (PPSV) 重复接种疫苗后,91.8%的人获得了保护性免疫力.
- 七名受试者表现出不充分的反应,其中五人患有复发性中耳炎;在一些人中发现了抗体缺乏和低血糖球蛋白血症等潜在疾病.
结论:
- 在患有复发性耳鼻喉疾病的儿科患者中,对肺炎球菌疫苗接种的不充分反应可能表明潜在的免疫问题.
- 这一发现表明了诊断途径,用于识别和治疗这个人群中的免疫缺陷.
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