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住院患者的高白血症:病因和结果
Joshua Y Kwon1, Paul J Nietert2, Don C Rockey3
1Division of Gastroenterology and Hepatology, University of California, Irvine, Orange, USA.
概括
住院患者的高白血常常是由肝病或癌症引起的,这表明预后不佳. 早期诊断和了解潜在原因对于患者的治疗结果至关重要.
科学领域:
- 内部医学 内部医学
- 胃肠病学 胃肠病学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 有限的数据存在于差异诊断和预后的 hyperbilirubinemia 在住院患者.
- 超白血症是一种重要的临床发现,需要对其潜在原因和对患者结果的影响进行调查.
研究的目的:
- 调查住院患者中高白血症的原因和相关结果.
- 为了确定与高白血症相关的特定疾病及其预后影响.
主要方法:
- 对1693名住院患者的回顾性队列分析,总 bilirubin >3 mg/dL.
- 收集的数据包括人口统计,诊断,查尔森并发症指数 (CCI),实验室值和临床结果.
- 患者被分为七个主要诊断组,以分析原因和结果.
主要成果:
- 主要肝病 (51%) 是最常见的高胆血病原因,其次是良性胆道阻塞 (15%) 和血液溶解性贫血 (9%).
- 整体死亡率/临终关怀医院出院率为30%,随着 bilirubin 严重程度的增加而增加.
- 主要肝病和恶性瘤患者的死亡率最高,非癌症阻塞或血溶性黄患者的死亡率最低.
结论:
- 住院患者的高 bilirubinemia 经常与原发性肝病相关.
- 住院患者胆红素水平升高表明预后不佳,特别是与肝病或恶性瘤有关.
- 了解超白血症的病因对于预测患者的结果至关重要.
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