在子中,神经假体的慢性稳定性包括多个相邻的犹他州阵列
Xing Chen1,2, Feng Wang1, Roxana Kooijmans1
1Department of Vision and Cognition, Netherlands Institute for Neuroscience, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
Journal of neural engineering
|June 30, 2023
概括
视力恢复的高通道神经假体显示出希望,但面临长期挑战. 对非人类灵长类动物的慢性植入显示,随着时间的推移,信号质量和刺激效率下降,需要改善临床使用.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 眼科医生 眼科 眼科
背景情况:
- 视觉皮层的电刺激可以产生,为盲人提供视力恢复的潜力.
- 目前的神经假肢设备仅限于96个通道,用于视觉皮层的慢性植入.
- 恢复功能视力需要高通道计数的神经假肢系统.
研究的目的:
- 评估1024通道神经假体系统在非人类灵长类动物 (NHPs) 的长期疗效和稳定性.
- 评估高通道计数器件对于慢性植入和视力恢复的适用性.
- 调查长期植入对神经信号质量,刺激效率和视觉任务性能的影响.
主要方法:
- 在两个的初级视觉皮层 (V1) 和视觉区域4 (V4) 中植入了16个犹他微电极阵列 (共1024个通道).
- 监测动物健康,电极阻抗和神经元信号质量 (SNR,波形振幅).
- 评估了素感知,视觉任务性能,并在植入后 (3-3,5年) 进行了组织学分析.
主要成果:
- 神经假肢系统在机械和电气上保持正常运行,动物保持健康.
- 随着时间的推移,观察到信号质量的逐渐下降,引电极数量的减少,电极阻抗的减少.
- 组织学分析显示皮质组织封装,变性和电极涂层的退化,与视觉任务性能受损相关.
结论:
- 在NHP视觉皮层中长期植入高通道计数的神经修复器件会导致组织变化和效率降低.
- 电极材料的降解和组织封装会对信号质量和刺激效率产生负面影响.
- 对于未来的视力恢复神经假体的临床转化,需要在设备生物相容性和植入技术方面取得显著的改进.
关键词:
犹他州的阵列组成了一个阵列.V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V4 V6 V4 V4 V4 V4 V4 V4 V6 V4 V4 V4 V4 V4 V6 V1 V1 V1 V1 V1 V1 V1 V2 V1 V1 V1 V2 V1 V1 V1 V1 V1 V2 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1 V1失明 失明 失明 失明微刺激微观刺激神经假体的神经假体非人类的灵长类灵长类动物.相关概念视频
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