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在接受过敏原免疫治疗的患者中,是否有理由补充维生素D?
Mario Di Gioacchino1, Claudia Petrarca2,3, Loredana Della Valle4
1Institute for Clinical Immunotherapy and Advanced Biological Treatments, Pescara, Italy.
Annals of medicine
|June 30, 2023
概括
维生素D (VD) 可能无法预防过敏,但可以增强过敏原免疫疗法 (AIT). 在AIT期间补充VD可以提高免疫反应和耐受性,特别是在缺陷患者中.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 内分泌学 在内分泌学.
背景情况:
- 维生素D (VD) 具有免疫调节作用,促进免疫耐受性.
- 风病已被研究用于治疗像过敏这样的免疫疾病,其中耐受性丧失是关键.
- 现有的文献提出了关于VD在预防或治疗过敏疾病中的作用的相互矛盾的证据.
研究的目的:
- 评估维生素D (VD) 在管理过敏疾病中的有效性.
- 调查静脉疾病对过敏敏感性和疾病严重性的影响.
- 为了确定VD是否在免疫治疗期间增强过敏原特异性免疫反应.
主要方法:
- 审查有关维生素D和过敏的现有文献.
- 分析研究的分析,调查VD对过敏敏感性的影响.
- 检查结合VD与过敏原免疫疗法 (AIT) 的临床试验.
主要成果:
- 视频疾病在预防或治疗过敏方面的直接作用仍在争论中.
- 视觉疾病显著增强了AIT诱导的耐受性反应.
- 静脉疾病与下语言AIT (LAIS) 的联合治疗显示出出色的临床和免疫反应,增强了调控性T细胞分化.
结论:
- 对于接受AIT的过敏患者,特别是那些缺乏或不足的患者,VD补充应该被认为是常规的.
- 结合VD和AIT似乎是治疗过敏的一个有希望的策略.
- 需要进一步的研究,以充分阐明VD在过敏敏感化和运动中的作用.
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