最近在基于PLGA的微针介导的皮肤透射药物和疫苗输送方面取得了进展
Atefeh Malek-Khatabi1, Malihe Sadat Razavi2,3, Alyeh Abdollahi1
1Department of Pharmaceutical Biomaterials and Medical Biomaterials Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Biomaterials science
|June 30, 2023
概括
聚合物微针 (MNs) 通过绕过皮肤屏障,提供最小侵入性药物和疫苗的输送. 本综述强调了基于聚乳糖醇酸 (PLGA) 的多种药物的进展,涵盖了它们的类型,应用和未来前景.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 制药科学 制药科学
背景情况:
- 微针 (MNs) 是先进的输送系统,可实现微侵袭性通过皮肤和皮肤内输送.
- 聚合物MN阵列,特别是那些由聚乳糖醇酸 (PLGA) 制成的阵列,由于其生物相容性和生物降解性而越来越突出.
- PLGA是一种FDA批准的共聚合物,使得基于PLGA的MNs成为治疗输送的安全有效选择.
研究的目的:
- 审查基于聚乳糖醇酸 (PLGA) 的微针 (MN) 技术的最新进展.
- 讨论各种治疗应用的基于纳米粒子的PLGA和基于矩阵的PLGAMN.
- 探索多种类型的MN及其潜在用途,以及未来的挑战和机遇.
主要方法:
- 关于基于PLGA的微针的最近研究的文献综述.
- 对PLGA MNs (基于纳米粒子和基于矩阵) 的不同制造方法的分析.
- 综合关于在药物,疫苗和蛋白质输送中的应用信息.
主要成果:
- 基于PLGA的MNs通过克服角层屏障,显示出增强药物和疫苗输送的巨大潜力.
- 基于纳米粒子和矩阵的PLGA MNs都是各种治疗剂的有效载体.
- 对PLGA MNs的广泛应用正在出现,包括有针对性的皮肤内输送.
结论:
- 基于PLGA的微针代表了通过皮肤和皮肤内输送系统的有希望的前沿.
- 对PLGA MNs的持续研究对于克服现有的挑战和充分实现其治疗潜力至关重要.
- PLGA的生物相容性和生物降解性支持其在创新的MN交付平台中的使用.
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