反复性皮肤真菌感染-一个越来越严重的问题
1Division of Dermatology, National Skin Centre, Singapore City, Singapore.
The Australasian journal of dermatology
|June 30, 2023
概括
由于各种抵抗机制和过度使用抗真菌药物,真菌皮肤感染中的抗真菌耐药性正在全球范围内增加. 新的治疗方法和负责任的抗真菌使用对于打击这种日益严重的公共卫生威胁至关重要.
科学领域:
- 菌类学 菌类学是指菌类学.
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
背景情况:
- 复发性真菌皮肤感染,包括耐胺的Trichophyton,Malassezia,Candida和非皮肤菌,在全球范围内正在增加.
- 抗真菌耐药性因在农业和医学中不分青红白地使用,卫生状况差以及特定的真菌耐药机制而加剧.
- 难以治疗的感染,如桃菌症,由于药物通过角质的透性较差,使其复杂化.
研究的目的:
- 审查皮肤真菌感染中抗真菌耐药性增加的发病率和流行率.
- 阐明真菌对抗真菌剂产生耐药性的多种机制.
- 讨论新的抗真菌治疗方法以及负责任的抗真菌管理的重要性.
主要方法:
- 对抗真菌耐药机制和新兴治疗方法的文献综述.
- 分析导致抗真菌耐药性的发展和传播的因素.
- 检查新批准的和正在研究的抗真菌药物.
主要成果:
- 菌类耐药机制包括目标改变,药物排放,无活化,途径绕道,应激适应和生物膜形成.
- 新的抗真菌药物如ibrexafungerp和oteseconazole提供了替代的作用机制和更好的选择性.
- 耐药性的发展与环境因素和患者的坚持有关.
结论:
- 打击抗真菌耐药性需要采取多方面的方法,包括开发新疗法和实施严格的抗真菌管理.
- 了解真菌耐药机制是设计有效治疗的关键.
- 需要在机构和个人层面共同努力,以制不适当的抗真菌使用和减轻耐药性.
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