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Updated: Jul 25, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
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可切换的通过电光催化对C-H键的直接氧化结合,通过电光催化

Yan Zhang1, Xiang Sun1, Ji-Hu Su2

  • 1Hefei National Center for Physical Sciences at Microscale, Key Laboratory of Precision and Intelligent Chemistry, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China.

Organic letters
|June 30, 2023
PubMed
概括

一种新的无金属方法使得使用电化学和安全的介质N-chloro-succinimide (NCS) 的可切换合成diaryl酒精和基. 这种方法激活非反应性基C-H键,以实现高效的配合.

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All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
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The stereochemistry of electrocyclic reactions is strongly influenced by the orbital symmetry of the polyene HOMO. Under thermal conditions, the reaction proceeds via the ground-state HOMO.
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