除了LL-37外,抗微生物的损失不是亚托皮肤炎的特征
Lilla Szabó1, Anikó Kapitány2, Orsolya Somogyi3
1Department of Dermatology, Centre of Excellence, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Gyula Petrányi Doctoral School of Allergy and Clinical Immunology, University of Debrecen, Debrecen, HungaryDepartment of Dermatology, Centre of Excellence, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Acta dermato-venereologica
|June 30, 2023
概括
抗微生物对亚托皮炎的皮肤屏障功能至关重要. 这项研究发现,抗微生物LL-37在受影响的皮肤和未受影响的皮肤中都降低了,这表明它在疾病发展中的作用.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 亚托匹性皮肤炎涉及皮肤屏障功能受损.
- 抗微生物 (AMP) 对于皮肤屏障的完整性至关重要.
- 缺乏对在亚托皮性皮肤炎中AMP功能组的全面研究.
研究的目的:
- 调查在亚托皮性皮肤炎中主要AMP功能组的表达.
- 为了比较病变性AD,非病变性AD和健康皮肤中的AMP.
- 作为疾病控制的病变性牛皮 psoriatic 皮肤中检查AMP.
主要方法:
- 实时定量PCR (qPCR) 用于mRNA表达.
- 免疫组织化学用于蛋白质表达.
- 病变性亚托邦皮肤炎,非病变性亚托邦皮肤炎,健康对照和病变性牛皮皮肤的分析.
主要成果:
- 在非损伤性AD和健康皮肤之间没有显著的mRNA差异.
- 与健康对照人群相比,LL-37蛋白在非损伤性AD中下降.
- 在病变性AD中,几个AMP显示了改变的mRNA,但蛋白质水平大多是上调或不变的,除了LL-37.
结论:
- 在非病变性和病变性亚托皮性皮肤炎中,LL-37具有独特的损伤.
- 降低LL-37可能在早期亚托皮性皮肤炎中发挥病原学或恶化的作用.
- 在病变性AD和牛皮的皮肤中,AMPs通常是上调调节的,除了LL-37.
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