作为中风的候选预后标志物,瘤起源性-2的可溶性抑制:系统性审查
Koohyar Ahmadzadeh1, Shayan Roshdi Dizaji1, Mohammad Balabandian2
1Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Annals of laboratory medicine
|June 30, 2023
概括
瘤发生性-2 (sST-2) 的血清可溶性抑制显示出预测中风结果的潜力,包括死亡率和残疾. 然而,它在预测中风发病率方面的作用需要进一步调查,因为结果相互矛盾.
科学领域:
- 心血管研究研究心血管研究
- 生物标志物发现发现
- 神经学 神经学
背景情况:
- 脑卒中风险分层对于治疗和康复计划至关重要.
- 作为一种潜在的生物标志物,正在研究血清可溶性瘤发生性-2 (sST-2) 的抑制.
研究的目的:
- 系统地审查关于血清sST-2对中风发病率和中风后结果的预测价值的文献.
主要方法:
- 在主要数据库 (Medline,Scopus,Web of Science,Embase) 进行了全面的文献搜索,截至2022年8月.
- 系统审查中包括了19篇相关文章.
主要成果:
- 关于sST-2对中风发病率的预测值,报告了相互矛盾的结果.
- 研究表明sST-2水平与中风后死亡率,不良事件,残疾,脑心综合征和认知障碍之间的积极关联.
结论:
- 由于不一致的发现,关于sST-2在预测中风发病率中的作用的共识缺乏.
- sST-2可以作为中风后死亡率,不良事件和残疾的预后标记.
- 需要进一步进行精心设计的前性研究,以确认sST-2的实用性并确定最佳的切断点.
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